Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function

Front Biosci. 2005 Jan 1;10:919-30. doi: 10.2741/1586. Print 2005 Jan 1.

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). Although the precise mechanism of HTLV-1 oncogenesis remains unclear, the pathogenesis has been linked to the pleiotropic activity of the viral transcriptional activator protein Tax. Tax has been shown to regulate viral and cellular gene expression and to functionally interfere with proteins involved in cell-cycle progression and DNA repair. This review will concentrate on the ability of Tax to promote cellular proliferation through activation of the NF-kappaB pathway while inhibiting the cell-cycle checkpoint and apoptotic function of the tumor suppressor gene p53.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Proliferation
  • Cell Transformation, Neoplastic*
  • DNA Repair
  • Gene Products, tax / chemistry*
  • Gene Products, tax / metabolism
  • Human T-lymphotropic virus 1 / metabolism*
  • Humans
  • NF-kappa B / metabolism
  • Terminal Repeat Sequences
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Gene Products, tax
  • NF-kappa B
  • Tumor Suppressor Protein p53