The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions

Br J Cancer. 2004 Dec 13;91(12):2056-62. doi: 10.1038/sj.bjc.6602253.


The presence of high-risk human papillomavirus, loss of heterozygosity on chromosome 3p and fragile histidine triad gene expression were assessed as potential markers of cancer and CIN progression in 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions. Human papillomavirus type 16 was an indicator of vascular involvement in cancers. Loss of heterozygosity, especially in the fragile histidine triad gene intron 5, was an indicator of high-grade tumours, greater tumour depth and lymph node involvement. Abnormal fragile histidine triad gene expression was more frequent in cervical intraepithelial neoplasia grade 1 lesions with increased risk of disease progression.

MeSH terms

  • Acid Anhydride Hydrolases / genetics*
  • Biomarkers, Tumor
  • Cervical Intraepithelial Neoplasia / genetics
  • Cervical Intraepithelial Neoplasia / pathology
  • Cervical Intraepithelial Neoplasia / virology
  • Chromosomes, Human, Pair 3 / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genotype
  • Humans
  • Loss of Heterozygosity
  • Neoplasm Proteins / genetics*
  • Papillomaviridae / genetics*
  • Papillomavirus Infections / complications*
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Prognosis
  • Tumor Virus Infections / complications*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / virology*


  • Biomarkers, Tumor
  • Neoplasm Proteins
  • fragile histidine triad protein
  • Acid Anhydride Hydrolases