Abstract
Urate is largely excluded from the brain under non-inflammatory conditions (concentration gradient serum:CSF about 10:1), but increases markedly in Guillain-Barré Syndrome and bacterial meningitis. The oxidation product allantoin is normally not passively distributed between blood and cerebrospinal fluid (gradient 3:1) and increases 5-fold in CSF of patients with meningitis. Patients with multiple sclerosis had normal levels of urate and allantoin in blood and CSF.
MeSH terms
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Allantoin / metabolism
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Blood-Brain Barrier
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Brain / metabolism
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Central Nervous System Diseases / blood
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Central Nervous System Diseases / cerebrospinal fluid
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Central Nervous System Diseases / pathology*
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Guillain-Barre Syndrome / blood
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Guillain-Barre Syndrome / cerebrospinal fluid
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Humans
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Inflammation / cerebrospinal fluid*
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Meningitis / blood
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Meningitis / cerebrospinal fluid
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Meningitis, Bacterial / blood
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Meningitis, Bacterial / cerebrospinal fluid
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Multiple Sclerosis / blood
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Multiple Sclerosis / cerebrospinal fluid
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Oxygen / metabolism*
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Uric Acid / metabolism*
Substances
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Uric Acid
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Allantoin
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Oxygen