Targeting mitochondrial ATP-sensitive potassium channels--a novel approach to neuroprotection

Brain Res Brain Res Rev. 2004 Nov;46(3):282-94. doi: 10.1016/j.brainresrev.2004.06.011.


Mitochondrial responses to ischemic stress play an important role in necrosis and apoptosis of brain cells. Recent studies using several different experimental preparations have shown that activation of ATP-sensitive potassium channels in mitochondria (mitoK(ATP) channels) is able to protect neurons and astroglia against injury and death. Thus, targeting of mitoK(ATP) channels appears to be a novel approach to neuroprotection. However, little is known about the mechanisms involved. The purpose of this review is to detail the current state of knowledge about this important, emerging area of investigation, and to provide suggestions for future studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology
  • Brain Ischemia / drug therapy
  • Brain Ischemia / metabolism*
  • Brain Ischemia / physiopathology
  • Cytoprotection / drug effects
  • Cytoprotection / physiology
  • Humans
  • Membrane Proteins / drug effects
  • Membrane Proteins / metabolism*
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Nerve Degeneration / drug therapy
  • Nerve Degeneration / metabolism*
  • Nerve Degeneration / physiopathology
  • Neuroprotective Agents / pharmacology
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology*
  • Potassium Channels


  • Membrane Proteins
  • Neuroprotective Agents
  • Potassium Channels
  • mitochondrial K(ATP) channel