Productive RUPture: Activation of Transcription Factors by Proteasomal Processing

Biochim Biophys Acta. 2004 Nov 29;1695(1-3):209-13. doi: 10.1016/j.bbamcr.2004.09.022.


Proteasomes usually degrade proteins completely into small peptides. In a few cases, however, proteasomal degradation rather results in protein processing, thereby yielding proteins of different biological activity. This process, termed "regulated ubiquitin/proteasome-dependent processing" or RUP, is essential for the function of certain transcription factors and crucial for their regulation. Examples are proteins of the mammalian NF-kappaB family and the yeast proteins SPT23 and MGA2. In this review, we summarize the available data and suggest a mechanistic model for proteasomal processing.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Proteasome Endopeptidase Complex / physiology*
  • Protein Processing, Post-Translational / physiology*
  • Transcription Factors / physiology*
  • Ubiquitin / physiology*


  • Transcription Factors
  • Ubiquitin
  • Proteasome Endopeptidase Complex