Consequences of regulated pre-mRNA splicing in the immune system

Nat Rev Immunol. 2004 Dec;4(12):931-40. doi: 10.1038/nri1497.


Alternative splicing is widely recognized to be a ubiquitous and crucial mechanism for generating protein diversity and regulating protein expression. Numerous immunologically relevant genes have been found to undergo alternative splicing; however, there has been little effort to develop a coherent picture of how alternative splicing might be used as a general mechanism to regulate the function of the immune system. In this review, I summarize the mechanisms by which splicing is controlled in T cells, and discuss the role of alternative splicing and alternative isoform expression in the regulation of T-cell activation and function.

Publication types

  • Review

MeSH terms

  • Alternative Splicing / immunology*
  • Hyaluronan Receptors / genetics
  • Immune System / physiology*
  • Leukocyte Common Antigens / genetics
  • Lymphocyte Activation / genetics
  • Models, Immunological*
  • T-Lymphocytes / immunology*


  • Hyaluronan Receptors
  • Leukocyte Common Antigens