AKAP signalling complexes: focal points in space and time

Nat Rev Mol Cell Biol. 2004 Dec;5(12):959-70. doi: 10.1038/nrm1527.


Multiprotein signalling networks create focal points of enzyme activity that disseminate the intracellular action of many hormones and neurotransmitters. Accordingly, the spatio-temporal activation of protein kinases and phosphatases is an important factor in controlling where and when phosphorylation events occur. Anchoring proteins provide a molecular framework that orients these enzymes towards selected substrates. A-kinase anchoring proteins (AKAPs) are signal-organizing molecules that compartmentalize various enzymes that are regulated by second messengers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • A Kinase Anchor Proteins
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Cycle Proteins
  • Cyclic AMP / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Macromolecular Substances*
  • Protein Binding
  • Protein Isoforms / metabolism
  • Proteins / metabolism
  • Receptors, Adrenergic, beta-2 / metabolism
  • Second Messenger Systems / physiology*
  • Time Factors
  • rho GTP-Binding Proteins / metabolism


  • A Kinase Anchor Proteins
  • AKAP12 protein, human
  • Adaptor Proteins, Signal Transducing
  • Cell Cycle Proteins
  • Macromolecular Substances
  • Protein Isoforms
  • Proteins
  • Receptors, Adrenergic, beta-2
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases
  • rho GTP-Binding Proteins