The DNA-polymerase-X family: controllers of DNA quality?

Nat Rev Mol Cell Biol. 2004 Dec;5(12):1038-43. doi: 10.1038/nrm1530.


Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA / metabolism*
  • DNA Damage
  • DNA Repair
  • DNA-Directed DNA Polymerase / chemistry
  • DNA-Directed DNA Polymerase / genetics
  • DNA-Directed DNA Polymerase / metabolism*
  • Humans
  • Models, Molecular
  • Multigene Family
  • Nucleic Acid Conformation
  • Protein Conformation


  • DNA
  • DNA polymerase X
  • DNA-Directed DNA Polymerase