Laboratory animal models of temporal lobe epilepsy

Comp Med. 2004 Oct;54(5):473-85.


Temporal lobe epilepsy is a common human disease that is difficult to treat. The pathogenesis of temporal lobe epilepsy, which holds many unresolved questions, and opportunities for creating more effective treatments and preventative strategies are reviewed herein. Laboratory animal models are essential to meet these challenges. How models are created, how they compare with each other and with the disease in human patients, and how they advance our understanding of temporal lobe epilepsy are described.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Laboratory*
  • Disease Models, Animal*
  • Epilepsy, Temporal Lobe* / etiology
  • Epilepsy, Temporal Lobe* / pathology
  • Epilepsy, Temporal Lobe* / physiopathology
  • Female
  • Humans
  • Male
  • Mice
  • Monkey Diseases / etiology
  • Monkey Diseases / pathology
  • Primates
  • Rats
  • Species Specificity