GOToolBox: functional analysis of gene datasets based on Gene Ontology

Genome Biol. 2004;5(12):R101. doi: 10.1186/gb-2004-5-12-r101. Epub 2004 Nov 26.


We have developed methods and tools based on the Gene Ontology (GO) resource allowing the identification of statistically over- or under-represented terms in a gene dataset; the clustering of functionally related genes within a set; and the retrieval of genes sharing annotations with a query gene. GO annotations can also be constrained to a slim hierarchy or a given level of the ontology. The source codes are available upon request, and distributed under the GPL license.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Databases, Genetic
  • Drosophila melanogaster / genetics
  • Genomics / methods*
  • Internet
  • Protein Interaction Mapping
  • Software*