Declines in serum free and bound choline concentrations in humans after three different types of major surgery

Clin Chem Lab Med. 2004;42(12):1390-5. doi: 10.1515/CCLM.2004.259.

Abstract

We examined the changes in circulating choline status in humans in response to major surgery by measuring serum free and phospholipid-bound choline concentrations before, during and 1-72 h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery. Preoperatively, the mean serum free and phospholipid-bound choline concentrations in patients scheduled for abdominal hysterectomy (n = 26), off-pump coronary artery grafting surgery (n = 34) or brain tumor surgery (n = 24) were 12.3 +/- 0.5, 12.1 +/- 0.4 and 11.4 +/- 0.4 micromol/l, and 2495 +/- 75, 2590 +/- 115 and 2625 +/- 80 micromol/l, respectively. Serum free choline and phospholipid-bound choline concentrations decreased from these baseline values to 8.8 +/- 0.7 (p < 0.001), 8.8 +/- 0.5 (p < 0.001) and 8.2 +/- 0.4 micromol/l (p < 0.001), and 2050 +/- 108 (p < 0.001), 2166 +/- 59 (p < 0.001) and 1884 +/- 104 micromol/l (p < 0.001) at 1 h after hysterectomy, off-pump bypass graft surgery or brain tumor surgery, respectively. They remained at these low levels for 24 h and then gradually increased towards the preoperative values at 48-72 h postoperatively. Serum cortisol increased postoperatively in all surgical patients for 24 h and its levels were inversely correlated with serum free and bound choline concentrations. These results show that circulating free and bound choline concentrations decrease for 72 h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery in humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brain Neoplasms / surgery*
  • Choline / blood*
  • Coronary Artery Bypass* / statistics & numerical data
  • Female
  • Humans
  • Hydrocortisone / blood
  • Hysterectomy* / statistics & numerical data
  • Male
  • Middle Aged
  • Neurosurgical Procedures* / statistics & numerical data
  • Phospholipids / blood
  • Time Factors
  • Uterine Neoplasms / surgery*

Substances

  • Phospholipids
  • Choline
  • Hydrocortisone