The Mammalian Cell Cycle: An Overview

Methods Mol Biol. 2005;296:113-53. doi: 10.1385/1-59259-857-9:113.


In recent years, we have witnessed major advances in our understanding of the mammalian cell cycle and how it is regulated. Normal mammalian cellular proliferation is tightly regulated at each phase of the cell cycle by the activation and deactivation of a series of proteins that constitute the cell cycle machinery. This review article describes the various phases of the mammalian cell cycle and focuses on the cell cycle regulatory molecules that act at each stage to ensure normal cellular progression.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / physiology
  • Cyclin-Dependent Kinases / physiology
  • Cyclins / physiology
  • Cytokinesis
  • DNA Replication
  • Mammals
  • Mitosis
  • Models, Biological


  • Cell Cycle Proteins
  • Cyclins
  • Cyclin-Dependent Kinases