Vitamin D(3) ointment is widely used for the therapy of inflammatory keratotic dermatoses such as psoriasis. Senile wart (seborrheic keratosis) is a benign tumor, which occurs mainly in the elderly. It has been treated with surgical procedures, freezing with liquid nitrogen, or laser therapy. We tried to treat senile wart with active forms of topical vitamin D(3) (tacalcitol, calcipotriol or maxacalcitol). These topical vitamin D(3) ointments were applied on senile warts once or twice a day. Out of 116 cases those were treated for more than three months, 35 cases (30.2%) showed excellent response that means more than 80% of decreasing of tumor volume, 54 cases (46.6%) showed moderate response that means 40 to 80% of decreasing, 27 cases (23.2%) showed no remarkable changes or decreasing less than 40%. The tumor disappeared without any inflammatory change such as erythema or swelling. Any of side effects were not observed on all patients whose senile warts were treated with topical vitamin D(3).