Comparison of capsule endoscopy and magnetic resonance imaging for the detection of polyps of the small intestine in patients with familial adenomatous polyposis or with Peutz-Jeghers' syndrome

Endoscopy. 2004 Dec;36(12):1054-9. doi: 10.1055/s-2004-826041.


Background and study aims: We have conducted a study to compare the diagnostic yields of magnetic resonance imaging (MRI) and capsule endoscopy for the detection of small-bowel polyps in patients with inherited polyposis syndromes.

Patients and methods: MRI was performed in 20 patients, with either Peutz-Jeghers' syndrome (PJS; n = 4) or familial adenomatous polyposis (FAP; n = 16), and capsule endoscopy was done the next day. The number, size, and location of polyps were analyzed.

Results: Overall, 448 polyps ranging from about 1 mm to 30 mm in size were detected in eight patients by capsule endoscopy, whereas with MRI only 24 polyps all bigger than 5 mm could be seen in the four PJS patients.

Conclusions: Polyps bigger than 15 mm were detected similarly with capsule endoscopy and MRI, whereas smaller polyps were seen much more often with capsule endoscopy. Polyps smaller than 5 mm were exclusively seen with capsule endoscopy. However, location of the detected polyps and determination of their exact sizes was more accurate by MRI.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adenomatous Polyposis Coli / complications
  • Adenomatous Polyposis Coli / pathology*
  • Adolescent
  • Adult
  • Capsules
  • Endoscopy, Gastrointestinal*
  • Female
  • Humans
  • Intestinal Polyps / etiology
  • Intestinal Polyps / pathology*
  • Intestine, Small / pathology
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Peutz-Jeghers Syndrome / complications
  • Peutz-Jeghers Syndrome / pathology*
  • Sensitivity and Specificity
  • Video Recording / instrumentation*


  • Capsules