Feedback control of Purkinje cell activity by the cerebello-olivary pathway

Eur J Neurosci. 2004 Dec;20(11):2999-3005. doi: 10.1111/j.1460-9568.2004.03789.x.


The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N-O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N-O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N-O fibres depressed climbing fibre responses and caused an increase in simple spike firing. These results are taken as support for the feedback hypothesis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Action Potentials / radiation effects
  • Afferent Pathways / drug effects
  • Afferent Pathways / physiology*
  • Afferent Pathways / radiation effects
  • Anesthetics, Local / pharmacology
  • Animals
  • Cerebellum / cytology*
  • Cerebellum / physiology
  • Dose-Response Relationship, Radiation
  • Electric Stimulation / methods
  • Feedback / physiology*
  • Ferrets
  • Lidocaine / pharmacology
  • Male
  • Olivary Nucleus / anatomy & histology
  • Olivary Nucleus / physiology*
  • Purkinje Cells / drug effects
  • Purkinje Cells / physiology*
  • Time Factors


  • Anesthetics, Local
  • Lidocaine