DNA vaccines: designing strategies against parasitic infections

Genet Vaccines Ther. 2004 Dec 3;2(1):17. doi: 10.1186/1479-0556-2-17.


The complexity of parasitic infections requires novel approaches to vaccine design. The versatility of DNA vaccination provides new perspectives. This review discusses the use of prime-boost immunizations, genetic adjuvants, multivalent vaccines and codon optimization for optimal DNA vaccine design against parasites.