Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome

J Pediatr. 2004 Dec;145(6):778-83. doi: 10.1016/j.jpeds.2004.08.022.


Objectives: To evaluate quality of life (QOL) and psychosocial adjustment by standardized tests in well-characterized patients with steroid-sensitive nephrotic syndrome.

Study design: Forty-five patients were investigated at a median age of 9.8 years (range, 3.4 to 19.8) and 5.9 years (range, 0.1 to 16.3) since diagnosis. Child- and parent-rated QOL was evaluated by the The Netherlands Organization for Applied Scientific Research Academical Medical Center (TNO-AZL) Child Quality of life Questionnaire. Psychosocial adjustment was assessed by the Child Behavior Checklist and the Teacher Report Form.

Results: In patients, only the QOL subscale "social functioning" was impaired compared with that in control subjects, whereas parents rated 4 of a total of 7 subscales as abnormal. Psychosocial adjustment was impaired at home and at school. Steroid dependency and cytotoxic treatment had a significant negative impact on QOL only, whereas family climate, especially maternal distress, negatively affected both QOL and psychosocial adjustment.

Conclusions: QOL and psychosocial adjustment are impaired in steroid-sensitive nephrotic syndrome. Both illness-related variables and family climate play an important role.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child Behavior*
  • Child, Preschool
  • Cross-Sectional Studies
  • Family
  • Female
  • Humans
  • Male
  • Nephrotic Syndrome / drug therapy
  • Nephrotic Syndrome / physiopathology
  • Nephrotic Syndrome / psychology*
  • Quality of Life*
  • Recurrence
  • Social Adjustment*
  • Surveys and Questionnaires
  • Switzerland