Prevention of intraventricular hemorrhage by indomethacin in male preterm infants

J Pediatr. 2004 Dec;145(6):832-4. doi: 10.1016/j.jpeds.2004.07.035.


Our multicenter Indomethacin Intraventricular Hemorrhage (IVH) Prevention Trial demonstrated a reduction of IVH in preterm infants. Analysis of our cohort by sex showed indomethacin halved the incidence of IVH, eliminated parenchymal hemorrhage, and was associated with higher verbal scores at 3 to 8 years in boys.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cardiovascular Agents / therapeutic use*
  • Cerebral Hemorrhage / prevention & control*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidence
  • Indomethacin / therapeutic use*
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight
  • Language Tests
  • Logistic Models
  • Male
  • Multicenter Studies as Topic
  • Randomized Controlled Trials as Topic
  • Sex Characteristics


  • Cardiovascular Agents
  • Indomethacin