Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy

J Pediatr. 2004 Dec;145(6):835-7. doi: 10.1016/j.jpeds.2004.07.034.


Twenty-six infants with hypoxic-ischemic encephalopathy (HIE) were randomized to normothermia or to systemic hypothermia. The hypothermia group had less cortical gray matter signal abnormality on magnetic resonance imaging (MRI) (1/12 vs 7/14 infants in the normothermic group; P = .036), which may indicate differing regional benefit from systemic hypothermia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electroencephalography
  • Gestational Age
  • Humans
  • Hypothermia, Induced / methods*
  • Hypoxia-Ischemia, Brain / therapy*
  • Infant, Newborn
  • Magnetic Resonance Imaging