Depot medroxyprogesterone acetate, oral contraceptives and bone mineral density in a cohort of adolescent girls

J Adolesc Health. 2004 Dec;35(6):434-41. doi: 10.1016/j.jadohealth.2004.07.005.

Abstract

Purpose: To conduct a longitudinal comparison of bone mineral density (BMD) in 370 adolescent girls, aged 12-18, who self-selected depot medroxyprogesterone acetate (DMPA) or an oral contraceptive (OC) containing 20 microg ethinyl estradiol/100 microg levonorgestrel with that in girls who received no hormonal treatment (control group).

Methods: Lumbar spine and femoral neck BMD measurements were obtained by dual energy x-ray absorptiometry at baseline and 12 months. Data were analyzed with repeated measures analysis of covariance methods.

Results: Over 12 months, lumbar spine BMD decreased in the DMPA group (n = 29), with a mean percent change of -1.4% (95% confidence interval [CI] -2.73, -0.10), and increased by a mean of 3.8% (95% CI 3.11, 4.57) in the control group [n = 107 (p < .001)]. The increase in mean percent change in lumbar spine BMD in the OC group (n = 79), 2.3% (95% CI 1.49, 3.18), was significantly smaller than in the control group (p = .03). Over 12 months, the mean percent change in femoral neck BMD was -2.2% (95% CI -3.95, -0.39) in the DMPA group, but increased 2.3% (95% CI 1.29, 3.27) in the control group (p < .001). The increase in mean percent change at the femoral neck in the OC group, 0.3% (95% CI -0.87, 1.41), was significantly lower than in the control group (p = .03).

Conclusions: Our study contributes to an increasing body of knowledge indicating a negative impact of DMPA on bone health in young women. Additional findings suggest a potential adverse effect of an OC containing 20 microg ethinyl estradiol/100 microg levonorgestrel on bone health in adolescents.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Absorptiometry, Photon
  • Adolescent
  • Adolescent Health Services / standards
  • Body Mass Index
  • Bone Demineralization, Pathologic / chemically induced*
  • Bone Demineralization, Pathologic / diagnostic imaging
  • Bone Demineralization, Pathologic / epidemiology
  • Bone Demineralization, Pathologic / prevention & control
  • Bone Density / drug effects*
  • Bone Development / drug effects
  • Cohort Studies
  • Confidence Intervals
  • Contraceptive Agents, Female / administration & dosage
  • Contraceptive Agents, Female / adverse effects*
  • Contraceptives, Oral, Hormonal / adverse effects
  • Contraceptives, Oral, Synthetic / adverse effects
  • Delayed-Action Preparations / adverse effects
  • Ethinyl Estradiol / administration & dosage
  • Ethinyl Estradiol / adverse effects*
  • Female
  • Femur Neck / metabolism
  • Health Education
  • Humans
  • Levonorgestrel / administration & dosage
  • Levonorgestrel / adverse effects*
  • Lumbar Vertebrae / metabolism
  • Medroxyprogesterone Acetate / administration & dosage
  • Medroxyprogesterone Acetate / adverse effects*
  • Odds Ratio
  • Prospective Studies
  • Risk Factors
  • Time Factors
  • United States / epidemiology

Substances

  • Contraceptive Agents, Female
  • Contraceptives, Oral, Hormonal
  • Contraceptives, Oral, Synthetic
  • Delayed-Action Preparations
  • Ethinyl Estradiol
  • Levonorgestrel
  • Medroxyprogesterone Acetate