Nutrient sensing and metabolic decisions

Comp Biochem Physiol B Biochem Mol Biol. 2004 Dec;139(4):543-59. doi: 10.1016/j.cbpc.2004.06.014.


Cells have several sensory systems that detect energy and metabolic status and adjust flux through metabolic pathways accordingly. Many of these sensors and signaling pathways are conserved from yeast to mammals. In this review, we bring together information about five different nutrient-sensing pathways (AMP kinase, mTOR, PAS kinase, hexosamine biosynthesis and Sir2), highlighting their similarities, differences and roles in disease.

Publication types

  • Review

MeSH terms

  • Adenylate Kinase / metabolism*
  • Animals
  • Hexosamines / metabolism*
  • Humans
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction / physiology
  • Sirtuins / metabolism*
  • TOR Serine-Threonine Kinases


  • Hexosamines
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • PAS domain kinases
  • Protein-Serine-Threonine Kinases
  • Adenylate Kinase
  • Sirtuins