PcMtr, an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum

Hein Trip; Melchior E Evers; Arnold J M Driessen

doi:10.1016/j.bbamem.2004.09.014

PcMtr, an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum

Biochim Biophys Acta. 2004 Dec 15;1667(2):167-73. doi: 10.1016/j.bbamem.2004.09.014.

Authors

Hein Trip¹, Melchior E Evers, Arnold J M Driessen

Affiliation

¹ Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands.

PMID: 15581852
DOI: 10.1016/j.bbamem.2004.09.014

Abstract

The gene encoding an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum was cloned, functionally expressed and characterized in Saccharomyces cerevisiae M4276. The permease, designated PcMtr, is structurally and functionally homologous to Mtr of Neurospora crassa, and unrelated to the Amino Acid Permease (AAP) family which includes most amino acid permeases in fungi. Database searches of completed fungal genome sequences reveal that Mtr type permeases are not widely distributed among fungi, suggesting a specialized function.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Transport Systems / chemistry
Amino Acid Transport Systems / genetics*
Amino Acid Transport Systems / metabolism
Amino Acids / chemistry
Amino Acids / metabolism
Amino Acids, Aromatic / metabolism
Carbon / metabolism
Carbon Radioisotopes
Cloning, Molecular
Genes, Fungal
Genetic Complementation Test
Kinetics
Molecular Sequence Data
Penicillium chrysogenum / enzymology*
Penicillium chrysogenum / genetics
Penicillium chrysogenum / growth & development
Phylogeny
Saccharomyces cerevisiae / genetics
Substrate Specificity

Substances

Amino Acid Transport Systems
Amino Acids
Amino Acids, Aromatic
Carbon Radioisotopes
Carbon

Associated data

GENBANK/AY628328