Reelin glycoprotein: structure, biology and roles in health and disease

Mol Psychiatry. 2005 Mar;10(3):251-7. doi: 10.1038/


Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autistic Disorder / physiopathology*
  • Cell Adhesion Molecules, Neuronal / physiology*
  • Extracellular Matrix Proteins / physiology*
  • Humans
  • Mice
  • Mice, Neurologic Mutants
  • Nerve Tissue Proteins / physiology*
  • Reelin Protein
  • Schizophrenia / physiopathology*
  • Serine Endopeptidases / physiology*
  • Signal Transduction / physiology*


  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Nerve Tissue Proteins
  • Reelin Protein
  • RELN protein, human
  • Reln protein, mouse
  • Serine Endopeptidases