Secretory carcinoma of the male breast: correlation of aspiration cytology and pathology

Diagn Cytopathol. 2005 Jan;32(1):47-50. doi: 10.1002/dc.20157.


Secretory carcinoma (SC) is a rare variant of breast carcinoma, which was first described in children and adolescents but it can occur at all ages. Very few cases have been reported in male patients. We describe the cytological and histopathological features of SC in a 79-yr-old man. Cytological findings demonstrated cohesive sheets of monotonous cells with round nuclei and small nucleoli. Most cells contained intracytoplasmic vacuoles, which are the key feature of an accurate diagnosis. Differential diagnosis with other tumors is discussed briefly.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy, Fine-Needle / methods*
  • Breast Neoplasms, Male / chemistry
  • Breast Neoplasms, Male / pathology*
  • Breast Neoplasms, Male / surgery
  • Carcinoma / chemistry
  • Carcinoma / pathology*
  • Carcinoma / surgery
  • Humans
  • Immunohistochemistry
  • Lymph Node Excision
  • Male
  • Mammography
  • Mastectomy
  • Treatment Outcome
  • Ultrasonography


  • Biomarkers, Tumor