[Acute renal failure and 2,8-dihydroxyadeninuria]

Nephrologie. 2004;25(7):297-300.
[Article in French]


We report the case of a 65 year old man, with a history of recurrent urolithiasis, who was referred for an acute renal failure. Investigations deny obstructive or glomerular involvement. 2,8-Dihydroxyadeninuria was diagnosed with the help of crystalluria. This rare metabolic disease is due to a deficiency of adenine phosphoribosyltransferase, a purine salvage enzyme. Allopurinol, a low purine diet and high fluid intake made possible the nearly entire regression of renal failure.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / therapy
  • Adenine / analogs & derivatives*
  • Adenine / urine*
  • Adenine Phosphoribosyltransferase / deficiency*
  • Aged
  • Humans
  • Male
  • Recurrence
  • Urinary Calculi / etiology


  • 2,8-dihydroxyadenine
  • Adenine Phosphoribosyltransferase
  • Adenine