Simple surface modification of poly(epsilon-caprolactone) for apatite deposition from simulated body fluid

Biomaterials. 2005 May;26(15):2407-13. doi: 10.1016/j.biomaterials.2004.07.048.

Abstract

Poly(epsilon-caprolactone) (PCL) with a bone-like apatite layer bound to its surface could be useful as a scaffold for tissue engineering applications. In the present study, the surface of PCL was treated with aqueous NaOH to introduce carboxylate groups onto the surface. The NaOH-treated material was subsequently dipped in aqueous CaCl(2) and K(2)HPO(4).3H(2)O alternately three times to deposit apatite nuclei on the surface. The surface-modified material successfully formed a dense and uniform bone-like surface apatite layer after incubation for 24 h in simulated body fluid with ion concentrations approximately equal to those of human blood plasma.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorbable Implants
  • Apatites / chemistry*
  • Biomimetic Materials / chemistry*
  • Body Fluids / chemistry*
  • Bone Substitutes / chemistry*
  • Materials Testing
  • Polyesters / chemistry*
  • Porosity
  • Surface Properties
  • Tissue Engineering / methods*

Substances

  • Apatites
  • Bone Substitutes
  • Polyesters
  • polycaprolactone