Histological evaluation of medial patellofemoral ligament reconstructed using the Leeds-Keio ligament prosthesis

Biomaterials. 2005 May;26(15):2663-70. doi: 10.1016/j.biomaterials.2004.07.053.


In a total of 15 knees from 15 patients undergoing medial patellofemoral ligament reconstruction using an artificial substitute and a medial retinaculum slip coverage for recurrent patellar dislocation, the reconstructed ligaments were histologically evaluated using hematoxilin-eosin and elastic van Gieson stains. The artificial substitute was a mesh-type Leeds-Keio ligament. The mean age of the patients at the time of surgery was 20 years (range; 13-38 years). The mean interval from initial reconstruction to gathering was 53 months (range; 11-109 months). In the tissue over the artificial ligament, longitudinally aligned collagen fiber bundles with spindle-shaped nuclei were formed in all specimens except one specimen of 11 months postsurgery, but it seemed to be mature ligament only in specimens more than 60 months postsurgery. The tissue inside the artificial ligament was immature as a whole in all specimens, although 13 out of the 15 specimens had regularly aligned collagen fiber bundles slightly or in some portions.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Equipment Failure Analysis
  • Female
  • Follow-Up Studies
  • Foreign-Body Reaction / etiology
  • Foreign-Body Reaction / pathology*
  • Humans
  • Knee Prosthesis / adverse effects*
  • Male
  • Patellar Dislocation / pathology*
  • Patellar Dislocation / surgery*
  • Prosthesis Failure*
  • Prosthesis-Related Infections / etiology
  • Prosthesis-Related Infections / pathology*
  • Reconstructive Surgical Procedures / adverse effects
  • Reconstructive Surgical Procedures / instrumentation*
  • Reconstructive Surgical Procedures / methods
  • Severity of Illness Index
  • Treatment Outcome