The link between PKCalpha regulation and cellular transformation

Immunol Lett. 2005 Jan 31;96(2):155-62. doi: 10.1016/j.imlet.2004.08.013.


Protein kinase Calpha (PKCalpha) is a serine/threonine protein kinase that has been implicated in the regulation of a variety of cellular functions such as proliferation, differentiation and apoptosis in response to a diverse range of stimuli. In order to execute these biological events PKCalpha activity is modulated by, and functionally interacts with, a number of proto-oncogenes, therefore it is perhaps unsurprising that dysregulation of PKCalpha is associated with a diverse range of cancers. Recently, PKCalpha has become a target for a number of anti-cancer therapies. The purpose of this review is to describe how PKCalpha regulates key biological events, to gain an insight into how PKCalpha-mediated cellular transformation may occur. In this way, it may be possible to design therapeutic tools to combat cancers specifically associated with PKCalpha dysfunction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Cell Transformation, Neoplastic / metabolism*
  • Drug Design
  • Humans
  • Protein Kinase C / metabolism*
  • Protein Kinase C-alpha


  • Antineoplastic Agents
  • PRKCA protein, human
  • Protein Kinase C
  • Protein Kinase C-alpha