Reproducibility of dopamine transporter density measured with 123I-FPCIT SPECT in normal control and Parkinson's disease patients

Ann Nucl Med. 2004 Oct;18(7):609-16. doi: 10.1007/BF02984583.


The objective of this study was to evaluate the reproducibility of 123I-FPCIT SPECT by using whole striatal region of interest (ROI) and subdivided ROI in normal controls (NC) and Parkinson's disease (PD) patients.

Methods: Ten NC and 6 PD received a SPECT scan for 6 hours postinjection of FPCIT. The distribution volume ratio (R(V)) and specific-nonspecific tissue activity ratio (RT) were measured as an outcome measure. The test/retest reproducibility of R(V) and R(T) was evaluated by calculating the test/retest difference, variability, and reliability.

Results: There were no significant test/retest differences for any regions in either the NC or PD. The test/retest variability/reliability of Rv was 5.53+/-4.12%/0.89 in NC, 4.50+/-5.31%/0.99 in PD with whole striatal ROI, 4.29+/-0.78%/ 0.94+/-0.03 in NC, and 6.87+/-1.23 %/0.98+/-0.01 in PD with subdivided ROI. The test/retest variability/reliability of RT was 11.1+/-10.4%/0.59 in NC, 7.84+/-8.94%/0.95 in PD with whole striatal ROI, 11.9+/-1.22%/0.65+/-0.06 in NC, and 12.2+/-4.00%/0.95+/-0.03 in PD with subdivided ROI.

Conclusion: R(V) is highly reproducible and reliable compared with RT in both NC and PD as an outcome measure.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Brain / diagnostic imaging*
  • Brain / metabolism*
  • Dopamine Plasma Membrane Transport Proteins
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Male
  • Membrane Glycoproteins / metabolism*
  • Membrane Transport Proteins / metabolism*
  • Middle Aged
  • Nerve Tissue Proteins / metabolism*
  • Parkinson Disease / diagnostic imaging*
  • Parkinson Disease / metabolism*
  • Radiopharmaceuticals / pharmacokinetics
  • Reference Values
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tissue Distribution
  • Tomography, Emission-Computed, Single-Photon / methods
  • Tropanes / pharmacokinetics*


  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Radiopharmaceuticals
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane