Assembly-disassembly of the nuclear lamina

Curr Opin Cell Biol. 1992 Feb;4(1):105-9. doi: 10.1016/0955-0674(92)90066-l.


Recently, progress in the study of lamins has been made in three areas: signals required for targetting newly synthesized lamins to the correct subnuclear compartment have been identified; information on lamina assembly has been obtained from in vitro studies using bacterially expressed proteins; and a mechanistic explanation for how the nuclear lamina is diassembled at the onset of mitosis is emerging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Chromatin / physiology
  • Lamins
  • Mitosis / physiology
  • Nuclear Matrix / physiology*
  • Nuclear Proteins / physiology*
  • Phosphorylation


  • Chromatin
  • Lamins
  • Nuclear Proteins