Intermediate filament dynamics

Curr Opin Cell Biol. 1992 Feb;4(1):99-104. doi: 10.1016/0955-0674(92)90065-k.


The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place. This incorporation appears to be required for maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational level, phosphorylation is an important factor in regulating dynamic aspects of intermediate filament organization and structure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Intermediate Filament Proteins / metabolism
  • Intermediate Filaments / metabolism
  • Intermediate Filaments / physiology*
  • Phosphorylation


  • Intermediate Filament Proteins