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Comparative Study
, 32 (3), 209-44

Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three in Vitro Embryotoxicity Tests

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Comparative Study

Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three in Vitro Embryotoxicity Tests

Elke Genschow et al. Altern Lab Anim.

Abstract

A detailed report is presented on the performance of the embryonic stem cell test (EST) in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded test chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly embryotoxic on the basis of their in vivo effects in animals and/or humans, were tested in four laboratories. The outcome showed that the EST can be considered to be a scientifically validated test, which is ready for consideration for use in assessing the embryotoxic potentials of chemicals for regulatory purposes.

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