Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature

Gynecol Oncol. 2005 Jan;96(1):235-40. doi: 10.1016/j.ygyno.2004.09.023.


Background: Granulosa cell tumors (GCTs) of the ovary are rare, hormonally active neoplasms characterized by endocrine manifestations, an indolent course, and late relapse.

Case: We report a case of a prolonged history of ovarian GCT managed primarily with repeat surgical resections.

Conclusion: This case illustrates the benefits of cytoreductive surgery for the management of recurrent disease, the use of serum tumor markers to help guide therapy, and the importance of extended follow-up.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Female
  • Granulosa Cell Tumor / blood
  • Granulosa Cell Tumor / pathology*
  • Granulosa Cell Tumor / secondary
  • Granulosa Cell Tumor / surgery
  • Humans
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local / blood
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / surgery
  • Ovarian Neoplasms / blood
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery