The mammalian TRPC cation channels

Biochim Biophys Acta. 2004 Dec 6;1742(1-3):21-36. doi: 10.1016/j.bbamcr.2004.08.015.


Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca(2+)-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as well as second messenger-operated channels in a variety of cell types. TRPC channels, together with other more distantly related channel families, make up the larger TRP channel superfamily. This review summarizes recent findings on the structure, regulation and function of the apparently ubiquitous TRPC cation channels.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Channels / chemistry
  • Calcium Channels / metabolism
  • Calcium Channels / physiology*
  • Protein Conformation
  • Second Messenger Systems
  • Structure-Activity Relationship
  • Terminology as Topic


  • Calcium Channels