Contrary to earlier outbreaks of cholera due to Vibrio cholerae O139 during 1993 and its reemergence in 1998 in and around Nagpur and only sporadic episodes thereafter for next couple of years, a large outbreak was encountered between June and October 2003. V. cholerae 01 El Tor were isolated in 198 cases, of which 152 were Ogawa, 3 Inaba, 4 Hikojima and 39 were non agglutinating (NAG) vibrios. No isolate of V. cholerae O139 was detected during the entire outbreak. The isolates were multi drug resistant to antibiotic susceptibility tests. This points to the resurgence of V. cholerae El Tor Ogawa causing outbreaks of cholera with a discernible increase in the incidence of multi drug resistant strains.