Does L-dopa treatment contribute to reduction in body weight in elderly patients with Parkinson's disease?

Acta Neurol Scand. 2005 Jan;111(1):12-20. doi: 10.1111/j.1600-0404.2004.00364.x.


Objective: Many patients with Parkinson's disease (PD) lose weight also early during the disease. The objective of the study was to investigate possible causative factors for this loss.

Materials and methods: In this report, 28 PD patients and 28 age- and sex-matched controls were repeatedly assessed with the focus on body weight, body fat mass, dysphagia, olfaction, physical activity, PD symptomatology and drug treatment.

Results: Weight loss was seen in PD patients both before and during L-dopa treatment.

Conclusion: The underlying disease could play a role, but our results also suggest that L-dopa per se could contribute to the weight loss.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antiparkinson Agents / adverse effects*
  • Deglutition Disorders / drug therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Levodopa / adverse effects*
  • Male
  • Motor Activity
  • Movement Disorders / drug therapy
  • Nausea / chemically induced
  • Parkinson Disease / drug therapy*
  • Smell
  • Weight Loss / drug effects*


  • Antiparkinson Agents
  • Levodopa