Viruses and Toll-like receptors

Microbes Infect. 2004 Dec;6(15):1356-60. doi: 10.1016/j.micinf.2004.08.013.

Abstract

Production of inflammatory cytokines and type I interferons by mammalian cells is mediated through virus-specific activation of Toll-like receptors (TLRs). Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytokines / biosynthesis*
  • Cytokines / genetics
  • Cytokines / metabolism
  • Humans
  • Membrane Glycoproteins / physiology*
  • Receptors, Cell Surface / physiology*
  • Toll-Like Receptors
  • Viruses / genetics
  • Viruses / immunology*
  • Viruses / pathogenicity*

Substances

  • Cytokines
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors