Visual perception in Parkinson disease dementia and dementia with Lewy bodies

Neurology. 2004 Dec 14;63(11):2091-6. doi: 10.1212/01.wnl.0000145764.70698.4e.


Objective: To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD).

Methods: The authors used a cross-sectional study to compare three demented groups matched for overall dementia severity (PDD: n = 24; DLB: n = 20; AD: n = 23) and two age-, sex-, and education-matched control groups (PD: n = 24, normal controls [NC]: n = 25).

Results: Visual perception was globally more impaired in PDD than in nondemented controls (NC, PD), but was not different from DLB. Compared to AD, PDD patients tended to perform worse in all perceptual scores. Visual perception of patients with PDD/DLB and visual hallucinations was significantly worse than in patients without hallucinations.

Conclusions: Parkinson disease dementia (PDD) is associated with profound visuoperceptual impairments similar to dementia with Lewy bodies (DLB) but different from Alzheimer disease. These findings are consistent with previous neuroimaging studies reporting hypoactivity in cortical areas involved in visual processing in PDD and DLB.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Cognition
  • Cohort Studies
  • Discrimination, Psychological
  • Extrapyramidal Tracts / physiopathology
  • Female
  • Form Perception
  • Hallucinations / etiology
  • Humans
  • Lewy Body Disease / complications*
  • Lewy Body Disease / psychology
  • Male
  • Motion Perception
  • Parkinson Disease / complications*
  • Parkinson Disease / psychology
  • Perceptual Disorders / etiology*
  • Psychomotor Performance
  • Reflex, Abnormal
  • Severity of Illness Index
  • Space Perception
  • Vision Tests
  • Visual Perception*