Histamine H3-receptor isoforms

Inflamm Res. 2004 Oct;53(10):509-16. doi: 10.1007/s00011-004-1286-9.


Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism
  • Central Nervous System / metabolism
  • Histamine Antagonists / pharmacology
  • Humans
  • Ligands
  • Models, Chemical
  • Molecular Sequence Data
  • Neurotransmitter Agents / metabolism
  • Protein Isoforms
  • Rats
  • Receptors, Histamine H3 / biosynthesis*
  • Receptors, Histamine H3 / chemistry*
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Tissue Distribution


  • Histamine Antagonists
  • Ligands
  • Neurotransmitter Agents
  • Protein Isoforms
  • Receptors, Histamine H3