Is iron oxide a tissue-specific contrast medium in diagnostic ultrasound? A case report

Ultraschall Med. 2004 Dec;25(6):448-9. doi: 10.1055/s-2004-813790.


We present a patient with Hodgkin's disease in whom computed tomography suggested focal lesions in the liver. As no lesions were detected by diagnostic ultrasound, magnetic resonance imaging (MRI) with iron oxide as contrast medium was performed for verification. MRI confirmed at least 3 small lesions. The ultrasound study performed immediately after this MRI scan easily detected these lesions. A biopsy was taken and histology showed infiltrates of Hodgkin's disease. The change in echogenicity of the liver and/or the lymphomatous tissue may be an effect of iron oxide. This observation has not been reported before.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Contrast Media*
  • Female
  • Ferric Compounds*
  • Hodgkin Disease / diagnostic imaging*
  • Hodgkin Disease / pathology
  • Humans
  • Liver / pathology
  • Neoplasm Staging
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed
  • Ultrasonography


  • Contrast Media
  • Ferric Compounds
  • ferric oxide