Adult-onset chorea and mitochondrial cytopathy

Mov Disord. 2005 Apr;20(4):490-492. doi: 10.1002/mds.20363.


We report on 2 adult patients presenting with choreic movements as the main clinical feature of mitochondrial cytopathy. One patient exhibited a sensory neuronopathy and ophthalmoplegia. The other had ptosis, a proximal myopathy, and a sensory neuropathy. The diagnosis of mitochondrial cytopathy was established by the presence of ragged red fibers, cytochrome C oxydase-negative fibers, and a defect of the complex IV of the respiratory chain in muscle biopsy. No mutations in mitochondrial DNA were detected. The choreic movements observed in juvenile forms of mitochondrial cytopathy are rarely observed in adults. Although striatal vulnerability is commonly reported in patients with mitochondrial disorders, the mechanism by which the mitochondrial dysfunction leads to chorea is not known.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Age of Onset
  • Biopsy
  • Cerebrospinal Fluid Proteins / metabolism
  • Chorea / genetics
  • Chorea / metabolism
  • Chorea / pathology*
  • Cognition Disorders / diagnosis
  • DNA Mutational Analysis
  • Female
  • Humans
  • Male
  • Mitochondrial Diseases / genetics
  • Mitochondrial Diseases / metabolism
  • Mitochondrial Diseases / pathology*
  • Muscle Fibers, Fast-Twitch / metabolism
  • Muscle Fibers, Fast-Twitch / pathology
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / pathology
  • Neuropsychological Tests


  • Cerebrospinal Fluid Proteins