Conditioned activity and instrumental reinforcement following long-term oral consumption of cocaine by rats

Behav Neurosci. 2004 Dec;118(6):1331-9. doi: 10.1037/0735-7044.118.6.1331.

Abstract

Food-reinforced conditioned activity and instrumental responding were measured in rats after 50 weeks of continuous access to a cocaine-saccharin solution in their home cages. The elevation of conditioned activity produced by acute access to the cocaine-saccharin solution in the home cage during testing was abolished by long-term preexposure to the cocaine solution, an effect that was reversed by systemic administration of cocaine immediately prior to testing. By contrast, chronic cocaine preexposure enhanced instrumental responding for both cocaine-sucrose and pure sucrose solutions. These results support the idea that long-term cocaine exposure enhances subsequent reinforcement.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal
  • Cocaine / administration & dosage
  • Cocaine / pharmacology*
  • Conditioning, Operant / drug effects*
  • Conditioning, Psychological / drug effects*
  • Corpus Striatum / metabolism
  • Dopamine / metabolism
  • Dopamine Uptake Inhibitors / administration & dosage
  • Dopamine Uptake Inhibitors / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Male
  • Prefrontal Cortex / metabolism
  • Rats
  • Reinforcement Schedule
  • Reinforcement, Psychology*
  • Saccharin / administration & dosage
  • Self Administration / methods
  • Serotonin / metabolism
  • Time
  • Time Factors

Substances

  • Dopamine Uptake Inhibitors
  • Serotonin
  • Saccharin
  • Cocaine
  • Dopamine