Acid sensing in renal epithelial cells

J Clin Invest. 2004 Dec;114(12):1696-9. doi: 10.1172/JCI23864.

Abstract

The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Line
  • Cytosol / metabolism
  • Enzyme Activation
  • Epithelial Cells / metabolism*
  • Focal Adhesion Kinase 2
  • Humans
  • Hydrogen-Ion Concentration
  • Kidney / cytology*
  • Kidney / metabolism
  • Kinetics
  • Models, Biological
  • Phosphorylation
  • Protein Binding
  • Protein Conformation
  • Protein-Tyrosine Kinases / metabolism
  • Protein-Tyrosine Kinases / physiology
  • Sodium-Hydrogen Exchanger 3
  • Sodium-Hydrogen Exchangers / chemistry
  • src-Family Kinases / metabolism*

Substances

  • Sodium-Hydrogen Exchanger 3
  • Sodium-Hydrogen Exchangers
  • Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 2
  • src-Family Kinases