Putting RNAs in the right place at the right time: RNA localization in the frog oocyte

Biol Cell. 2005 Jan;97(1):19-33. doi: 10.1042/BC20040067.


Localization of maternal mRNAs in many developing organisms provides the basis for both initial polarity during oogenesis and patterning during embryogenesis. Prominent examples of this phenomenon are found in Xenopus laevis, where localized maternal mRNAs generate developmental polarity along the animal/vegetal axis. Targeting of mRNA molecules to specific subcellular regions is a fundamental mechanism for spatial regulation of gene expression, and considerable progress has been made in defining the underlying molecular pathways.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cell Polarity / physiology*
  • Female
  • Oocytes / metabolism
  • Oocytes / physiology*
  • Protein Biosynthesis / genetics*
  • Protein Biosynthesis / physiology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • RNA, Messenger, Stored / genetics
  • RNA, Messenger, Stored / metabolism
  • Xenopus laevis / metabolism
  • Xenopus laevis / physiology


  • RNA, Messenger
  • RNA, Messenger, Stored