Clinical trial experience with fat-restricted vs. carbohydrate-restricted weight-loss diets

Obes Res. 2004 Nov;12 Suppl 2:141S-4S. doi: 10.1038/oby.2004.279.


It is unlikely that one diet is optimal for all overweight or obese persons. Both low-fat and low-carbohydrate diets have been shown to induce weight loss and reduce obesity-related comorbidities. Low-carbohydrate diets cause greater short-term (up to 6 months) weight loss than low-fat diets, but the long-term clinical safety and efficacy of these diets has not been studied.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Body Composition
  • Clinical Trials as Topic*
  • Diet
  • Diet, Fat-Restricted*
  • Diet, Reducing*
  • Dietary Carbohydrates / administration & dosage*
  • Energy Intake
  • Energy Metabolism
  • Humans
  • Lipids / blood
  • Obesity / diet therapy*
  • Randomized Controlled Trials as Topic
  • Time Factors
  • Weight Loss*


  • Dietary Carbohydrates
  • Lipids