Prevention of peritendinous adhesions following flexor tendon injury with seprafilm

Ann Plast Surg. 2004 Dec;53(6):560-4. doi: 10.1097/


Peritendinous adhesions are the most important complication of flexor tendon injury. In this study, Seprafilm was used for the prevention of peritendinous adhesions following flexor tendon repair. Seprafilm Bioresorbable Membrane (Genzyme Corporation, Cambridge, MA) contains sodium hyaluronate and carboxymethyl cellulose. Thirty New Zealand white male rabbits were divided equally into 3 groups. In all groups, the deep flexor tendon of the third finger of the left back foot was cut and repaired by Kessler-Tajima suture technique. In the first study group following tendon repair, Seprafilm was wrapped around the repaired tendon. In the second study group, sodium hyaluronate gel was injected to the operation field after tendon repair. In the control group, no external material was applied to the field. The study groups had better range of motion. Histopathologically, study groups had less adhesions compared with the control groups. As a result, it was concluded that in rabbit the peritendinous adhesions following flexor tendon repairs could be lowered with Seprafilm and hyaluronic acid.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biocompatible Materials / therapeutic use*
  • Carboxymethylcellulose Sodium / therapeutic use
  • Disease Models, Animal
  • Hyaluronic Acid / therapeutic use
  • Male
  • Membranes, Artificial*
  • Rabbits
  • Tendon Injuries / therapy*
  • Tendons / pathology
  • Time Factors
  • Tissue Adhesions / prevention & control
  • Wound Healing / drug effects


  • Biocompatible Materials
  • Membranes, Artificial
  • Seprafilm
  • Hyaluronic Acid
  • Carboxymethylcellulose Sodium