Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 432 (7019), 855-61

Navigating Chemical Space for Biology and Medicine

Affiliations
Review

Navigating Chemical Space for Biology and Medicine

Christopher Lipinski et al. Nature.

Abstract

Despite over a century of applying organic synthesis to the search for drugs, we are still far from even a cursory examination of the vast number of possible small molecules that could be created. Indeed, a thorough examination of all 'chemical space' is practically impossible. Given this, what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?

Similar articles

See all similar articles

Cited by 148 articles

See all "Cited by" articles

LinkOut - more resources

Feedback