Neonatal septicaemia in the neonatal care unit, Al-Anbar governorate, Iraq

East Mediterr Health J. Jul-Sep 2002;8(4-5):509-14.

Abstract

Neonatal septicaemia is a major cause of morbidity and mortality in developing countries. We studied 118 neonates admitted to the main referral hospital in Al-Anbar with positive blood cultures. The incidence of neonatal septicaemia for babies born at this hospital was 9.2 per 1000 live births, and mortality was 28%. Staphylococcus aureus (39%), Klebsiella pneumoniae (30%) and Escherichia coli (21%) constituted 90% of all isolates. The isolates showed in vitro susceptibility to cefotaxime, chloramphenicol and gentamicin, but resistance to more commonly used antibiotics such as ampicillin and cloxacillin. We recommend initial gentamicin/cefotaxime combined therapy while awaiting culture and sensitivity test results. Our study highlights the importance of understanding the local epidemiology of neonatal septicaemia in formulating a rational antibiotics policy.

MeSH terms

  • Bacteremia / congenital*
  • Bacteremia / drug therapy
  • Bacteremia / epidemiology*
  • Bacteremia / microbiology
  • Cefotaxime / therapeutic use
  • Drug Resistance, Bacterial
  • Drug Therapy, Combination / therapeutic use
  • Escherichia coli Infections / congenital
  • Escherichia coli Infections / epidemiology
  • Female
  • Gentamicins / therapeutic use
  • Hospital Mortality
  • Humans
  • Incidence
  • Infant Mortality
  • Infant, Newborn
  • Intensive Care Units, Neonatal*
  • Iraq / epidemiology
  • Klebsiella Infections / congenital
  • Klebsiella Infections / epidemiology
  • Klebsiella pneumoniae
  • Male
  • Microbial Sensitivity Tests
  • Morbidity
  • Population Surveillance
  • Prospective Studies
  • Referral and Consultation
  • Risk Factors
  • Staphylococcal Infections / congenital
  • Staphylococcal Infections / epidemiology
  • Staphylococcus aureus

Substances

  • Gentamicins
  • Cefotaxime