Primary prevention of acute coronary events through the adoption of a Mediterranean-style diet

East Mediterr Health J. 2002 Jul-Sep;8(4-5):593-602.


We evaluated the role of a Mediterranean-style diet in preventing acute coronary syndromes (ACS). Data from CARDIO2000, a multi-centre retrospective case-control study investigating the association between ACS and demographic, nutritional, lifestyle and medical risk factors were used. We studied 661 patients hospitalized for a first ACS event and 661 matched controls without clinical suspicion of cardiovascular disease. The Mediterranean diet significantly reduced (by 16%) the risk of developing ACS. The association remained significant in the presence of hypertension, hypercholesterolaemia, sedentary lifestyle, diabetes mellitus or a combination of two of these cardiovascular risk factors. Our findings illustrate the importance of the Mediterranean diet in the primary prevention of acute coronary events.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Aged
  • Bias
  • Case-Control Studies
  • Confounding Factors, Epidemiologic
  • Coronary Disease / epidemiology*
  • Coronary Disease / etiology
  • Coronary Disease / prevention & control*
  • Diabetes Complications / complications
  • Diet, Mediterranean*
  • Feeding Behavior
  • Female
  • Greece / epidemiology
  • Humans
  • Hypercholesterolemia / complications
  • Hypertension / complications
  • Life Style
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Obesity / complications
  • Primary Prevention / methods*
  • Primary Prevention / standards
  • Risk Factors
  • Risk Reduction Behavior
  • Smoking / adverse effects