Extracellular matrix and visual cortical plasticity: freeing the synapse

Neuron. 2004 Dec 16;44(6):905-8. doi: 10.1016/j.neuron.2004.12.008.


The effects of monocular deprivation (MD) on the ocular dominance of visual cortical neurons are a paradigmatic example of experience-dependent plasticity. Here we review recent data showing that extracellular matrix (ECM) plays an important role in the control of experience-dependent plasticity both in the developing and adult visual cortex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Extracellular Matrix / physiology*
  • Humans
  • Neuronal Plasticity / physiology*
  • Synapses / metabolism*
  • Visual Cortex / physiology*